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于乐祥  
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电子邮件: yulexiang@mail.kiz.ac.cn
通讯地址: 云南省昆明市盘龙区龙欣路17号 中国科学院昆明动物研究所    650201
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  简  历

于乐祥,博士,中科院昆明动物所研究员。2019年毕业于中科院生物物理所,获得理学博士学位,同年起于约翰霍普金斯大学、哥伦比亚大学从事博士后研究,2025年加入昆明动物所,组建系统代谢生物学学科组担任PI。目前在Cell Metabolism(2023、2024、2025), Science Advances, Biomaterial等杂志发表论文20余篇。

  研究方向

1.代谢性炎症的分子机制

聚焦系统代谢性炎症相关代谢免疫的调控机制和多学科交叉研究解析慢性炎症代谢性损伤的功能机制;结合非人灵长类生理病理模型分析,解析巨噬细胞调控代谢性炎症的分子机制。

2.代谢损伤的调控机制

研究病理过程代谢损伤的共性触发机制,解析糖脂代谢失衡在代谢性疾病中的异质性和调控的机制,探索干预改善代谢稳态的新策略。

  代表性成果和所获奖项
  承担国家重大科技任务
  代表论著

1.?Yu L, Yang YX, Gong Z, Wan Q, Du Y, Zhou Q, Xiao Y, Zahr T, Wang Z, Yu Z, Yang K, Geng J, Fried s, Li J, Haeusler RA, Leong KW, Bai L, Sun L, Wang P, Zhu BT, Wang L#, Qiang L#. FcRn-dependent IgG Accumulation in Adipose Tissue Unmasks Obesity Pathophysiology. Cell Metabolism. 2025, Doi.org/10.1016/j.cmet.2024.11.001.?

2.???Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski A, Wang S, Shao Z, Liao C, Kennedy B, Ding L, Zha S, Que J, LeDuc C A, Sun L, Wang L#, Qiang L#. IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metabolism. 2024. Doi.org/10.1016/j.cmet.2024.01.015.Accompanied Commentaries in Nature Aging, Nature Reviews in Endocrinology and Science signaling?

3.???Zhou Q*, Yu L*, Cook JR, Qiang L#, Sun L#. Deciphering the decline of metabolic elasticity in aging and obesity. Cell Metabolism. 2023 Aug 18; S1550-4131(23)00296-6.Highlighted and recommended in the Cell Metabolism: DOI: 10.1016/j.cmet.2023.08.006 & Nature Reviews Endocrinology: DOI: 10.1038/s41574-023-00914-4?

4.???Yu L#, Gao Y, Aaron N, and Qiang L#. A glimpse of the connection between PPARγ and macrophage. Front. Pharmacol. 2023 14:1254317. doi: 10.3389/fphar.2023.1254317?

5.???Yu L#. New Perspectives on Cancer Applicability of Falcon Systems Studies of Lipotoxicity. J Mod Med Oncol, 2023; 3: 8. DOI: 10.53964/jmmo.2023008.?

6.???Yu L, Chen Y, Wei Y#, He R#. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging (Albany NY) 2019, 11(14):4943-4969.?

7.???Chen Y*, Yu L*, Wang Y, Wei Y, He R. D-Ribose is a major contributor to the glycation of serum protein. Biochim Biophys Acta Mol Basis of Disease, 2019, DOI.org/10.1016/j.bbadis.2019.05.005.?

8.????Kang N*, Yu L*, Liu Y, He R. Changes in Ribose and Ribokinase in STZ-induced Type 2 Diabetic Rat. Progress in Biochemistry and Biophysics, 2023, DOI.org/10.16476/j.pibb.2023.0150.?

9.???Cao X*, Yu L*, Wei Y, Qu M, He R. Changes in Ribose, AGEs and Transketolase in Female GK Rat, a Type 2 Diabetic Model. Progress in Biochemistry and Biophysics, 2022, DOI.org/10.16476/j.pibb.2022.0161.?

10.?? Lyu J *, Yu L*, He Y, Wei Y, He R. A brief study of the correlation of urine ribose with MMSE scores of Alzheimer’s patients and cognitively normal participants. American Journal of Urology Research, 2019, 4(1):018-023.?

11.?? Wu B *, Yu L*, Hu P, Lu Y, Li J, Wei Y#, He R#. GRP78 protects CHO cells from ribosylation.? Biochim Biophys Acta Mol Cell Res, 2018, 1865(4):629-637.?

12.?? Zahr T, Boda V, Ge J, Yu L, Wu Z, Que J, Li W, Qiang L#, Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery, Acta Pharmaceutica Sinica B, 2024, ISSN 2211-3835.?

13.?? He Y, Zhang R, Yu L, Zahr T, Li X, Qiang L. Adipocyte PPARγ acetylation exacerbates BAT whitening and worsens aging-associated metabolic dysfunction. Cells. 2023 May; 12(10): 1424.?

14.?? Huang B, Wan Q, Li T, Yu L, Du W, Carmen C, Leong KW#, Qiang L#. Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity. Biomaterials. 2023 Feb; 293:121850. PMID: 36450630.?

15.?? He Y, Taus AB, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L. PPARγ acetylation orchestrates adipose plasticity and metabolic rhythms. Advanced Science. 2023 Jan; 10(2):e2204190.??

16.?? Aaron N, Zahr T, He Y, Yu L, Mayfield B, Pajvani UB, Qiang L. Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity. Life Metabolism. December 2022, Vol 1 (3), 258–269.?

17.?? Aaron N, Kraakman MJ, Zhou Q, Liu Q, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo JC, Wang W, Zhao B, Guo EX, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. Elife. 2021 Jun 22;10:e69209. doi: 10.7554/eLife.69209.?

18.?? Liu L, Chan M, Yu L, Wang W, Qiang L. Adipsin deficiency does not impact atherosclerosis development in Ldlr-/- mice. AJP-Endocrinology and Metabolism, 2021 Jan 1;320(1):E87-E92.?

19.?? Andrisse S, Feng M, Wang Z, Awe O, Yu L, Zhang H, Bi S, Wang H, Li L, Joseph S, Heller N, Jarvis F, Wong G, Segars J, Wolfe A Divall, S, Ahima R, Wu S. Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females. FASEB J. 2021 Oct; 35(10):e21921. doi: 10.1096/fj.202100961R.?

20.?? Chen Y, Yu L, Wei Y, Long Y, Xu Y, He T, He R. D-ribose increases triglyceride via upregulation of DGAT in the liver, Sci China Life Sci (1674-7305), 2019, DOI.org/10.1007/s11427-01909542-2.?

21.?? Wu B, Wang Y, Shi C, Chen Y, Yu L, Li J, Li W, Wei Y, He R. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. Journal of Alzheimer's disease: JAD 2019 Jul 26. doi: 10.3233/JAD-190158.?

22.?? Wang Y, Shi C, Chen Y, Yu L, Li Y, Wei Y, Li W, He R. Formaldehyde produced from d-ribose under neutral and alkaline conditions. Toxicol Rep. 2019 Apr 1;6:298-304. doi: 10.1016/j.toxrep.2019.02.005.?

23.?? Liu K, Liu Y, He Y, Yu L, Chen Y, He R. Elevated formaldehyde in the cecum of APP/PS1 mouse, Microbiology China 44(8) (2017) 1761-1766.


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